Prevalence and antimicrobial sensitivity pattern of bacteria causing urinary tract infection: A comparative study between men and women

Abstract

Urinary Tract Infections (UTI) are one of the most common bacterial infections in routine clinical practice. It is also the most common nosocomial infection in many hospitals. Study of causative agents and their Antimicrobial sensitivity pattern are important factors helping formulating antibiotic policy. Generally, the most common uropathogen is Escherichia coli. Tertiary care hospitals, catering for already partially treated or maltreated patients as major chunk, may have different etiological agents and sensitivity pattern. Objectives: To study prevalence of pathogens causing UTI among patients .Urinary tract infections (UTIs) are among the most common bacterial infections in humans, accounting for 3.5 billion in health care expenditures yearly in the United States alone. Yet, treatments for UTI have seen little innovation over the past decade. As demonstrated in other body sites, such as the vagina and gastrointestinal (GI) tract, acute and infectious diseases often have indirect microbial contributions which serve as intriguing new targets for therapies. The recent discovery of the existence of a resident community of bacteria (i.e., microbiota) in the bladders of both women and men represents a novel avenue for targeting UTIs. However, before targeted approaches aimed at modulating the urinary microbiota can be thoroughly investigated, it is first necessary to understand the normal modulations of these bacteria in the context of the host. Temporal dynamics in the vaginal and GI microbiota have been well described, and often linked to lifestyle factors or behaviors. Rigorous, longitudinal studies are required to study these trends. To date, few studies have assessed the urinary microbiota in such a manner none were comprehensive, and all were in the context of lower urinary tract symptoms. This is primarily due to the impracticality of collecting repeated transurethral catheterized urine specimens for analysis. Therefore, through our study, we compared the most common bacteria that cause this infection to both women and me. We obtained a set of conclusions that resulted in several recommendations